Fibroblast Activation Protein (FAP) specific PET for advanced target volume delineation in glioblastoma
نویسندگان
چکیده
منابع مشابه
Fibroblast activation protein (FAP) as a novel metabolic target
OBJECTIVE Fibroblast activation protein (FAP) is a serine protease belonging to a S9B prolyl oligopeptidase subfamily. This enzyme has been implicated in cancer development and recently reported to regulate degradation of FGF21, a potent metabolic hormone. Using a known FAP inhibitor, talabostat (TB), we explored the impact of FAP inhibition on metabolic regulation in mice. METHODS To address...
متن کاملGlioblastoma growth modeling for radiotherapy target delineation
Radiotherapy treatment planning requires a localization of the tumor within the patient. This is challenging to accomplish for microscopic infiltrative spread of disease that is not visible on current imaging modalities. Prime examples for infiltrative tumors are gliomas. With the help of mathematical models, common growth characteristics of gliomas, which are known from histopathological studi...
متن کاملFDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma
BACKGROUND FDG-PET/CT imaging has an emerging role in staging and treatment planning of various tumor locations and a number of literature studies show that also the carcinoma of the anal canal may benefit from this diagnostic approach. We analyzed the potential impact of FDG-PET/CT in stage definition and target volume delineation of patients affected by carcinoma of the anal canal and candida...
متن کاملRadiotherapy planning for glioblastoma based on a tumor growth model: improving target volume delineation.
Glioblastoma differ from many other tumors in the sense that they grow infiltratively into the brain tissue instead of forming a solid tumor mass with a defined boundary. Only the part of the tumor with high tumor cell density can be localized through imaging directly. In contrast, brain tissue infiltrated by tumor cells at low density appears normal on current imaging modalities. In current cl...
متن کاملAutomated biological target volume delineation for radiotherapy treatment planning using FDG-PET/CT
BACKGROUND This study compared manually delineated gross tumour volume (GTV) and automatically generated biological tumour volume (BTV) based on fluoro-deoxy-glucose (FDG) positron emission tomography (PET)/CT to assess the robustness of predefined PET algorithms for radiotherapy (RT) planning in routine clinical practice. METHODS RT-planning data from 20 consecutive patients (lung- (40%), oe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2020
ISSN: 0167-8140
DOI: 10.1016/j.radonc.2020.06.040